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Break-up changes brain chemistry in women

     Washington: A new study conducted by researches at University of T|bingen Medical Center in T|bingen, Germany suggests that a romantic break up in women can trigger brain changes visible on MRI scans. The team led by lead researcher Arif Najib found that women generally suffer more emotionally following the breakup of a romantic relationship than men,but during depression, the brain may have a malfunctioning of the normal circuitry for handling sadness, separation, and grief. Najib and colleagues chose 11 female volunteers who were in the throes of grief over a recent breakup of a romantic relationship. Many were having trouble getting it out of their minds -- a risk factor for major depression. They looked at brain scans while grieving women focused on sad thoughts about their romantic relationship. Then they performed brain imaging scans while women had neutral thoughts of a different person they had known for an equally long time. During the study, the women were still having difficulty getting the loss out of their minds, but most had resolved their depressive symptoms. Women still grieving over the romantic relationship had the greatest brain changes. Although there was increased brain activity in many regions associated with sadness, they also had much less activity in the brain region associated with emotion, motivation, and attention - the amygdala. A similar thing happens with anxiety disorders and posttraumatic stress disorder (PTSD) -- there is less amygdala activity rather than more, he explains. His findings regarding grieving after a breakup lay the groundwork for future studies of the connection between normal sadness, grief, and depression, he writes.
- Dec 31, 2004

Haldi helps fight Alzheimer's (Go To Top)

     Washington: Curcumin, the yellow pigment in curry spice may be a potential agent to fight against Alzheimer's, according to researchers at the University of California at Irvine. The new UCLA-Veterans Affairs study involving genetically altered mice suggests that curcumin, the yellow pigment in curry spice, inhibits the accumulation of destructive beta amyloids in the brains of Alzheimer's patients and also breaks up existing plaques. The research team also determined curcumin is more effective in inhibiting formation of the protein fragments than many other drugs being tested as Alzheimer's treatments. "Curcumin has been used for thousands of years as a safe anti- inflammatory in a variety of ailments as part of Indian traditional medicine," Gregory Cole, Professor of medicine and neurology at the David Geffen School of Medicine at UCLA said. "Recent successful studies in animal models support a growing interest in its possible use for diseases of aging involving oxidative damage and inflammation like Alzheimer's, cancer and heart disease. What we really need, however, are clinical trials to establish safe and effective doses in aging patients," he added.
-Dec 29, 2004

A cherry a day can keep diabetes away (Go To Top)

     Washington: In a new study, researchers at Michigan State University have identified a group of naturally occurring chemicals abundant in cherries that could help lower blood sugar levels in people with diabetes. Laboratory studies using animal pancreatic cells indicate that the chemicals, called anthocyanins, increased insulin production by 50 percent. Anthocyanins are a class of plant pigments responsible for the color of many fruits, including cherries. They also are potent antioxidants, highly active chemicals that have been increasingly associated with a variety of health benefits, including protection against heart disease and cancer. "It is possible that consumption of cherries and other fruits containing these compounds [anthocyanins] could have a significant impact on insulin levels in humans," study leader Muralee Nair said. Until human studies are done on cherry anthocyanins, those with diabetes should continue following their doctor's treatment recommendations, including any medicine prescribed, and monitor their insulin carefully, the researchers said. The team tested several types of anthocyanins extracted from these cherries against mouse pancreatic-beta cells, which normally produce insulin, in the presence of high concentrations of glucose.Insulin is the protein produced by the pancreas that helps regulate blood sugar (glucose) levels. Compared to cells that were not exposed to anthocyanins, exposed cells were associated with a 50 percent increase in insulin levels although the mechanism of action by which these anthocyanins boost insulin production is not known.
- Dec 21, 2004

SCI Biological pacemaker can be made with human embryonic stem (Go To Top)

     Washington: Johns Hopkins University researchers have found the first evidence that genetically engineered heart cells derived from human embryonic stem (ES) cells might one day turn out to be a promising biological alternative to the electronic pacemakers used by hundreds of thousands of people worldwide. Human ES cells were genetically engineered by the researchers to make a green protein, grown in the lab and then encouraged to become heart cells. They then selected clusters of the cells that beat on their own accord, indicating the presence of pacemaking cells. These clusters triggered the unified beating of heart muscle cells taken from rats, and, when implanted into the hearts of guinea pigs, triggered regular beating of the heart itself. "These implanted cells also responded appropriately to drugs used to slow or speed the heart rate, which electronic pacemakers can't do. But many challenges remain before this technique could be used for patients. We want to bring this to the clinic as fast as possible, but we need to be extremely careful. If this process isn't done properly, it could jeopardize a very promising field," said Ronald Li, lead author of the study and an assistant professor of medicine at Hopkins. "To our knowledge, these are the first genetically engineered heart cells derived from human ES cells. We're now using genetic engineering to customize the pacing rate of these cells, for example. For any future clinical applications, you want to make sure that the beating rate is what you want it to be," added Tian Xue, a post-doctoral researcher at Hopkins.
- Dec 21, 2004

Simple joys, not moolah, the key to happiness (Go To Top)

     Washington: Believe it or not, it is not the moolah, but the simplest of the daily activities that determine how happy we are in our daily life, reveals a report published in an issue of Science. According to University of Michigan psychologist Norbert Schwarz, a co-author of the Science article, simple daily routines like watching TV, eating, exercising etc, hold the key to our happiness and the report reveals that intimate relations form the most enjoyable part of life, while commuting is least enjoyed. The researchers analysed questionnaires completed by a convenience sample of 909 working women and found that activities like intimate relations, socialising, relaxing, praying or meditating, eating, exercising, and watching TV were among the most enjoyable activities. Interactions with friends and relatives were rated as the most enjoyable, followed by activities with spouses or significant others, children, clients or customers, co-workers and bosses. At the bottom of the list were the activities done alone. Commuting emerged as the most detestable activity, followed by working, doing housework, using the computer for e-mail or Internet, and taking care of children rounding out the bottom of the list. The report also reveals that personal characteristics such as trouble maintaining enthusiasm or a poor night's sleep also have an effect on how happy or sad we feel at a given day. Ironically, the researchers found that most of us, spend the maximum of our day's time doing activities which we enjoy the least, work, housework and commuting. Dec 4, 2004

Green tea can prevent prostate cancer (Go To Top)

     Washington: A new research to be published in the journal 'Cancer Research' has found that the polyphenols present in green tea help prevent the spread of prostate cancer. They do so by targeting molecular pathways that shut down the proliferation and spread of tumour cells, as well as inhibiting the growth of tumour nurturing blood vessels. The researchers from the University of Wisconsin, documented the role of green tea polyphenols (GTP) in modulating the insulin- like growth factor-1 (IGF-1)-driven molecular pathway in prostate tumour cells in a mouse model for human prostate cancer. They found that the consumption of GTP led to reduced levels of IGF-1. It was also found that GTP also led to increased levels of one of the binding proteins for IGF-1, the insulin growth factor binding protein-3. These observations bear significance in light of studies that indicate increased levels of IGF-1 are associated with increased risk of several cancers, such as prostate, breast, lung and colon. GTP also caused reduced expression of proteins known to be associated with the metastatic spread of cancer cells. GTP inhibited the levels of urokinase plasminogen activator as well as matrix metalloproteinases 2 and 9, cellular molecules linked to the metastasis. The green tea polyphenols contributed to minimizing tumour development by governing the amount of vascular endothelial growth factor (VEGF) in the serum of the prostate cancer mouse model.
- Dec 2, 2004


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